| Tuesday, November 3rd |
| | N Illinois Huskies | 32 | @ | 27 | Toledo Rockets |  | 8:00 PM EST | | The Glass Bowl | |
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| Wednesday, November 4th |
| | Ohio Bobcats | 24 | @ | 62 | Bowling Green Falcons | | 8:00 PM EST | | Doyt L. Perry Stadium | ESPN2 |
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| Thursday, November 5th |
| | Buffalo Bulls | 18 | @ | 17 | Kent St Golden Flashes | | 7:00 PM EST | | Dix Stadium | |
| | Ball St Cardinals | 7 | @ | 54 | W Michigan Broncos | | 7:30 PM EST | | Waldo Stadium | |
| | Arkansas St Red Wolves | 40 | @ | 27 | Appalachian St Mountaineers |  | 7:30 PM EST | | Kidd Brewer Stadium | |
| | Baylor Bears #6 | 31 | @ | 24 | Kansas St Wildcats |  | 7:30 PM EST | | Bill Snyder Family Stadium | FS1 |
| | Miss State Bulldogs #20 | 31 | @ | 13 | Missouri Tigers |  | 9:00 PM EST | | Faurot Field at Memorial Stadium | ESPN |
| | Nevada Wolf Pack | 30 | @ | 16 | Fresno State Bulldogs |  | 10:30 PM EST | | Bulldog Stadium | |
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| Friday, November 6th |
| | Temple Owls #22 | 60 | @ | 40 | SMU Mustangs |  | 8:00 PM EST | | Gerald Ford Stadium | ESPN2 |
| | Rice Owls | 21 | @ | 24 | UTEP Miners |  | 8:00 PM EST | | Sun Bowl | |
| | BYU Cougars | 17 | @ | 16 | San Jose St Spartans | | 11:30 PM EST | | CEFCU Stadium | CBBSN |
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| Saturday, November 7th |
| | FAU Owls | 19 | @ | 35 | W Kentucky Hilltoppers | | 12:00 PM EST | | Houchens Industries-L.T. Smith Stadium | |
| | Texas Tech Red Raiders | 26 | @ | 31 | West Virginia Mountaineers | | 12:00 PM EST | | Mountaineer Field at Milan Puskar Stadium | |
| | Notre Dame Fighting Irish #5 | 42 | @ | 30 | Pittsburgh Panthers | | 12:00 PM EST | | Heinz Field | |
| | Illinois Fighting Illini | 48 | @ | 14 | Purdue Boilermakers |  | 12:00 PM EST | | Ross-Ade Stadium | |
| | Akron Zips | 17 | @ | 13 | Massachusetts Minutemen | | 12:00 PM EST | | Gillette Stadium | |
| | UCF Knights | 30 | @ | 45 | Tulsa Golden Hurricane | | 12:00 PM EST | | Skelly Field at H. A. Chapman Stadium | |
| | Kentucky Wildcats | 3 | @ | 27 | Georgia Bulldogs | | 12:00 PM EST | | Sanford Stadium | |
| | Duke Blue Devils | 31 | @ | 66 | North Carolina Tar Heels |  | 12:00 PM EST | | Kenan Memorial Stadium | |
| | Penn State Nittany Lions | 21 | @ | 23 | Northwestern Wildcats #21 | | 12:00 PM EST | | Ryan Field | |
| | Charlotte 49ers | 31 | @ | 48 | Florida Int Golden Panthers | | 12:00 PM EST | | Riccardo Silva Stadium | |
| | Vanderbilt Commodores | 7 | @ | 9 | Florida Gators #10 | | 12:00 PM EST | | Ben Hill Griffin Stadium at Florida Field | |
| | Syracuse Orange | 17 | @ | 41 | Louisville Cardinals | | 12:30 PM EST | | Papa John's Cardinal Stadium | |
| | NC State Wolfpack | 24 | @ | 8 | Boston College Eagles | | 12:30 PM EST | | Alumni Stadium | |
| | Stanford Cardinal #11 | 42 | @ | 10 | Colorado Buffaloes |  | 1:00 PM EST | | Folsom Field | |
| | LA-Lafayette Ragin' Cajuns | 23 | @ | 21 | Georgia St Panthers | | 2:00 PM EST | | Georgia Dome | |
| | E Michigan Eagles | 13 | @ | 28 | Miami (OH) RedHawks | | 2:30 PM EST | | Fred C. Yager Stadium | |
| | Colorado St Rams | 26 | @ | 7 | Wyoming Cowboys | | 3:00 PM EST | | Jonah Field at War Memorial Stadium | |
| | Idaho Vandals | 45 | @ | 52 | South Alabama Jaguars | | 3:00 PM EST | | Ladd-Peebles Stadium | |
| | Virginia Cavaliers | 21 | @ | 27 | Miami (FL) Hurricanes | | 3:00 PM EST | | Hard Rock Stadium | |
| | LA-Monroe Warhawks | 14 | @ | 51 | Troy Trojans | | 3:30 PM EST | | Veterans Memorial Stadium | |
| | Cincinnati Bearcats | 30 | @ | 33 | Houston Cougars #25 | | 3:30 PM EST | | John O'Quinn Field at TDECU Stadium | |
| | Arkansas Razorbacks | 53 | @ | 52 | Ole Miss Rebels #18 | | 3:30 PM EST | | Vaught-Hemingway Stadium | CBS |
| | Marshall Thundering Herd | 24 | @ | 27 | Mid Tennessee Blue Raiders | | 3:30 PM EST | | Johnny Red Floyd Stadium | |
| | FSU Seminoles #16 | 13 | @ | 23 | Clemson Tigers #1 | | 3:30 PM EST | | Memorial Stadium | |
| | Rutgers Scarlet Knights | 16 | @ | 49 | Michigan Wolverines #17 | | 3:30 PM EST | | Michigan Stadium | |
| | TCU Horned Frogs #8 | 29 | @ | 49 | Oklahoma St Cowboys #14 | | 3:30 PM EST | | Boone Pickens Stadium | |
| | Iowa Hawkeyes #9 | 35 | @ | 27 | Indiana Hoosiers | | 3:30 PM EST | | Memorial Stadium | |
| | Utah St Aggies | 13 | @ | 14 | New Mexico Lobos | | 3:30 PM EST | | Dreamstyle Stadium | |
| | Wisconsin Badgers | 31 | @ | 24 | Maryland Terrapins | | 3:30 PM EST | | Capital One Field at Byrd Stadium | |
| | North Texas Mean Green | 13 | @ | 56 | Louisiana Tech Bulldogs | | 3:30 PM EST | | Joe Aillet Stadium | |
| | ASU Sun Devils | 24 | @ | 38 | Washington St Cougars | | 3:30 PM EST | | Martin Stadium | |
| Army Black Knights | 3 | @ | 20 | Air Force Falcons | | 3:30 PM EST | | Falcon Stadium | ESPN |
| | South Carolina Gamecocks | 24 | @ | 27 | Tennessee Volunteers | | 4:00 PM EST | | Neyland Stadium | |
| | Connecticut Huskies | 7 | @ | 3 | Tulane Green Wave | | 4:00 PM EST | | Mercedes-Benz Superdome | |
| | New Mexico St Aggies | 31 | @ | 21 | Texas St Bobcats | | 4:00 PM EST | | Jim Wacker Field at Bobcat Stadium | |
| | UCLA Bruins #23 | 41 | @ | 0 | Oregon St Beavers | | 4:30 PM EST | | Reser Stadium | |
| | Hawaii Warriors | 21 | @ | 41 | UNLV Rebels | | 6:00 PM EST | | Sam Boyd Stadium | |
| | Michigan St Spartans #7 | 38 | @ | 39 | Nebraska Cornhuskers | | 7:00 PM EST | | Memorial Stadium | ABC |
| | Old Dominion Monarchs | 36 | @ | 31 | UTSA Roadrunners | | 7:00 PM EST | | Alamodome | |
| | Iowa St Cyclones | 16 | @ | 52 | Oklahoma Sooners #15 | | 7:00 PM EST | | Gaylord Family-Oklahoma Memorial Stadium | |
| | Navy Midshipmen | 45 | @ | 20 | Memphis Tigers #13 | | 7:00 PM EST | | Liberty Bowl Memorial Stadium | |
| | USF Bulls | 22 | @ | 17 | East Carolina Pirates | | 7:30 PM EST | | Bagwell Field at Dowdy-Ficklen Stadium | |
| | Utah Utes #12 | 34 | @ | 23 | Washington Huskies | | 7:30 PM EST | | Alaska Airlines Field at Husky Stadium | |
| | Auburn Tigers | 26 | @ | 10 | Texas A&M Aggies #19 | | 7:30 PM EST | | Kyle Field | SECN |
| LSU Tigers #2 | 16 | @ | 30 | Alabama Crimson Tide #4 | | 8:00 PM EST | | Bryant-Denny Stadium | |
| | Kansas Jayhawks | 20 | @ | 59 | Texas Longhorns | | 8:00 PM EST | | Darrell K Royal - Texas Memorial Stadium | |
| | Minnesota Golden Gophers | 14 | @ | 28 | OSU Buckeyes #3 | | 8:00 PM EST | | Ohio Stadium | ABC |
| | Cal Golden Bears | 28 | @ | 44 | Oregon Ducks | | 10:30 PM EST | | Autzen Stadium | |
| | Arizona Wildcats | 30 | @ | 38 | USC Trojans | | 10:30 PM EST | | Los Angeles Memorial Coliseum | ESPN |