| Tuesday, November 17th |
| | Toledo Rockets | 44 | @ | 28 | Bowling Green Falcons |  | 6:00 PM EST | | Doyt L. Perry Stadium | |
| | Ball St Cardinals | 31 | @ | 48 | Ohio Bobcats | | 7:00 PM EST | | Peden Stadium | |
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| Wednesday, November 18th |
| | Cent Michigan Chippewas | 27 | @ | 14 | Kent St Golden Flashes | | 8:00 PM EST | | Dix Stadium | |
| | W Michigan Broncos | 19 | @ | 27 | N Illinois Huskies | | 8:00 PM EST | | Brigham Field at Huskie Stadium | |
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| Thursday, November 19th |
| | East Carolina Pirates | 44 | @ | 7 | UCF Knights |  | 7:30 PM EST | | Camping World Stadium | ESPN |
| | LA-Monroe Warhawks | 3 | @ | 16 | Texas St Bobcats |  | 9:30 PM EST | | Jim Wacker Field at Bobcat Stadium | |
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| Friday, November 20th |
| | Cincinnati Bearcats | 27 | @ | 65 | USF Bulls | | 8:00 PM EST | | Raymond James Stadium | |
| | Air Force Falcons | 37 | @ | 30 | Boise St Broncos |  | 9:30 PM EST | | Albertsons Stadium | |
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| Saturday, November 21st |
| | Citadel Bulldogs | 23 | @ | 22 | South Carolina Gamecocks | | 12:00 PM EST | | Williams-Brice Stadium | |
| | Iowa St Cyclones | 35 | @ | 38 | Kansas St Wildcats |  | 12:00 PM EST | | Bill Snyder Family Stadium | |
| | Rutgers Scarlet Knights | 31 | @ | 21 | Army Black Knights | | 12:00 PM EST | | Michie Stadium | CBSSN |
| | FAU Owls | 14 | @ | 20 | Florida Gators #8 | | 12:00 PM EST | | Ben Hill Griffin Stadium at Florida Field | |
| | Memphis Tigers #21 | 12 | @ | 31 | Temple Owls | | 12:00 PM EST | | Lincoln Financial Field | |
| | North Carolina Tar Heels #17 | 30 | @ | 27 | Virginia Tech Hokies |  | 12:00 PM EST | | Lane Stadium | |
| | Illinois Fighting Illini | 23 | @ | 32 | Minnesota Golden Gophers |  | 12:00 PM EST | | TCF Bank Stadium | |
| | Michigan Wolverines #12 | 28 | @ | 16 | Penn State Nittany Lions | | 12:00 PM EST | | Beaver Stadium | |
| | West Virginia Mountaineers | 49 | @ | 0 | Kansas Jayhawks | | 12:00 PM EST | | Memorial Stadium | |
| | Purdue Boilermakers | 20 | @ | 40 | Iowa Hawkeyes #5 | | 12:00 PM EST | | Kinnick Stadium | |
| | North Texas Mean Green | 7 | @ | 41 | Mid Tennessee Blue Raiders |  | 12:00 PM EST | | Johnny Red Floyd Stadium | |
| | Indiana Hoosiers | 47 | @ | 28 | Maryland Terrapins | | 12:00 PM EST | | Capital One Field at Byrd Stadium | |
| | Syracuse Orange | 29 | @ | 42 | NC State Wolfpack | | 12:30 PM EST | | Wayne Day Family Field at Carter-Finley Stadium | |
| | Georgia Tech Yellowjackets | 21 | @ | 38 | Miami (FL) Hurricanes | | 12:30 PM EST | | Hard Rock Stadium | |
| | Miami (OH) RedHawks | 20 | @ | 13 | Massachusetts Minutemen | | 1:00 PM EST | | Warren McGuirk Alumni Stadium | |
| | South Alabama Jaguars | 10 | @ | 24 | Georgia St Panthers | | 2:00 PM EST | | Georgia Dome | |
| | W Kentucky Hilltoppers | 63 | @ | 7 | Florida Int Golden Panthers | | 2:30 PM EST | | Riccardo Silva Stadium | |
| | Fresno State Bulldogs | 10 | @ | 52 | BYU Cougars | | 3:00 PM EST | | LaVell Edwards Stadium | |
| | Chattanooga Mocs | 13 | @ | 52 | FSU Seminoles #14 | | 3:00 PM EST | | Bobby Bowden Field at Doak Campbell Stadium | |
| | Northwestern Wildcats #20 | 13 | @ | 7 | Wisconsin Badgers #25 | | 3:30 PM EST | | Camp Randall Stadium | |
| | Wake Forest Demon Deacons | 13 | @ | 33 | Clemson Tigers #1 | | 3:30 PM EST | | Memorial Stadium | |
| | Michigan St Spartans #9 | 17 | @ | 14 | OSU Buckeyes #3 | | 3:30 PM EST | | Ohio Stadium | |
| | Louisiana Tech Bulldogs | 17 | @ | 15 | UTEP Miners | | 3:30 PM EST | | Sun Bowl | |
| Arizona Wildcats | 37 | @ | 52 | ASU Sun Devils |  | 3:30 PM EST | | Sun Devil Stadium | |
| USC Trojans #24 | 28 | @ | 48 | Oregon Ducks #23 | | 3:30 PM EST | | Autzen Stadium | |
| | LSU Tigers #15 | 17 | @ | 38 | Ole Miss Rebels #22 |  | 3:30 PM EST | | Vaught-Hemingway Stadium | |
| | Buffalo Bulls | 21 | @ | 42 | Akron Zips | | 3:30 PM EST | | InfoCision Stadium | |
| | Houston Cougars #19 | 17 | @ | 20 | Connecticut Huskies | | 3:30 PM EST | | Pratt and Whitney Stadium at Rentschler Field | |
| | Nevada Wolf Pack | 27 | @ | 31 | Utah St Aggies | | 3:30 PM EST | | Merlin Olsen Field at Maverik Stadium | |
| | Old Dominion Monarchs | 31 | @ | 56 | Southern Miss Golden Eagles | | 3:30 PM EST | | M.M. Roberts Stadium | |
| | UCLA Bruins | 17 | @ | 9 | Utah Utes #13 | | 3:30 PM EST | | Rice-Eccles Stadium | |
| | Duke Blue Devils | 34 | @ | 42 | Virginia Cavaliers | | 3:30 PM EST | | Scott Stadium | |
| | Louisville Cardinals | 34 | @ | 45 | Pittsburgh Panthers | | 3:45 PM EST | | Heinz Field | |
| | Idaho Vandals | 34 | @ | 56 | Auburn Tigers | | 4:00 PM EST | | Jordan-Hare Stadium | |
| | CSU Buccaneers | 6 | @ | 56 | Alabama Crimson Tide #2 | | 4:00 PM EST | | Bryant-Denny Stadium | |
| | New Mexico St Aggies | 37 | @ | 34 | LA-Lafayette Ragin' Cajuns | | 5:00 PM EST | | Cajun Field | |
| | Colorado St Rams | 28 | @ | 21 | New Mexico Lobos | | 5:30 PM EST | | Dreamstyle Stadium | |
| | Washington Huskies | 52 | @ | 7 | Oregon St Beavers | | 6:00 PM EST | | Reser Stadium | |
| | Rice Owls | 24 | @ | 34 | UTSA Roadrunners | | 7:00 PM EST | | Alamodome | |
| | Georgia Southern Eagles | 17 | @ | 23 | Georgia Bulldogs | | 7:00 PM EST | | Sanford Stadium | |
| | Navy Midshipmen #16 | 44 | @ | 21 | Tulsa Golden Hurricane | | 7:00 PM EST | | Skelly Field at H. A. Chapman Stadium | |
| | Miss State Bulldogs | 51 | @ | 50 | Arkansas Razorbacks | | 7:00 PM EST | | Donald W. Reynolds Razorback Stadium | |
| | Tennessee Volunteers | 19 | @ | 8 | Missouri Tigers | | 7:15 PM EST | | Faurot Field at Memorial Stadium | |
| | Boston College Eagles | 16 | @ | 19 | Notre Dame Fighting Irish #4 | | 7:30 PM EST | | Fenway Park | NBC |
| | Baylor Bears #10 | 45 | @ | 35 | Oklahoma St Cowboys #6 | | 7:30 PM EST | | Boone Pickens Stadium | |
| | Charlotte 49ers | 10 | @ | 58 | Kentucky Wildcats | | 7:30 PM EST | | Kroger Field | |
| | Texas A&M Aggies | 25 | @ | 0 | Vanderbilt Commodores | | 7:30 PM EST | | Vanderbilt Stadium | |
| | Tulane Green Wave | 21 | @ | 49 | SMU Mustangs | | 8:00 PM EST | | Gerald Ford Stadium | |
| | TCU Horned Frogs #18 | 29 | @ | 30 | Oklahoma Sooners #7 | | 8:00 PM EST | | Gaylord Family-Oklahoma Memorial Stadium | |
| | Cal Golden Bears | 22 | @ | 35 | Stanford Cardinal #11 | | 10:30 PM EST | | Stanford Stadium | |
| | San Diego St Aztecs | 52 | @ | 14 | UNLV Rebels | | 10:30 PM EST | | Sam Boyd Stadium | |
| | Colorado Buffaloes | 3 | @ | 27 | Washington St Cougars | | 10:45 PM EST | | Martin Stadium | |
| | San Jose St Spartans | 42 | @ | 23 | Hawaii Warriors | | 11:00 PM EST | | Hawaiian Tel Federal Credit Union Field | |