| Tuesday, November 24th |
| | Bowling Green Falcons | 48 | @ | 10 | Ball St Cardinals |  | 7:00 PM EST | | Scheumann Stadium | |
| | Ohio Bobcats | 26 | @ | 21 | N Illinois Huskies | | 7:30 PM EST | | Brigham Field at Huskie Stadium | |
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| Thursday, November 26th |
| | USF Bulls | 44 | @ | 3 | UCF Knights |  | 7:30 PM EST | | Camping World Stadium | ESPN |
| | Texas Tech Red Raiders | 48 | @ | 45 | Texas Longhorns |  | 7:30 PM EST | | Darrell K Royal - Texas Memorial Stadium | FS1 |
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| Friday, November 27th |
| | Marshall Thundering Herd | 28 | @ | 49 | W Kentucky Hilltoppers |  | 12:00 PM EST | | Houchens Industries-L.T. Smith Stadium | |
| | W Michigan Broncos | 35 | @ | 30 | Toledo Rockets #24 | | 12:00 PM EST | | The Glass Bowl | |
| | Kent St Golden Flashes | 0 | @ | 20 | Akron Zips | | 12:00 PM EST | | InfoCision Stadium | |
| | Miami (FL) Hurricanes | 29 | @ | 24 | Pittsburgh Panthers |  | 12:00 PM EST | | Heinz Field | ABC |
| | Navy Midshipmen #15 | 31 | @ | 52 | Houston Cougars | | 12:00 PM EST | | John O'Quinn Field at TDECU Stadium | |
| | E Michigan Eagles | 28 | @ | 35 | Cent Michigan Chippewas | | 1:00 PM EST | | Kelly/Shorts Stadium | |
| | Troy Trojans | 21 | @ | 31 | Georgia St Panthers |  | 2:00 PM EST | | Georgia Dome | |
| | Missouri Tigers | 3 | @ | 28 | Arkansas Razorbacks |  | 2:30 PM EST | | Donald W. Reynolds Razorback Stadium | CBS |
| | Iowa Hawkeyes #4 | 28 | @ | 20 | Nebraska Cornhuskers |  | 3:30 PM EST | | Memorial Stadium | |
| | Washington St Cougars #20 | 10 | @ | 45 | Washington Huskies |  | 3:30 PM EST | | Alaska Airlines Field at Husky Stadium | |
| | Boise St Broncos | 40 | @ | 23 | San Jose St Spartans |  | 3:30 PM EST | | CEFCU Stadium | |
| | Oregon St Beavers | 42 | @ | 52 | Oregon Ducks #17 | | 4:00 PM EST | | Autzen Stadium | |
| | Massachusetts Minutemen | 31 | @ | 26 | Buffalo Bulls | | 4:30 PM EST | | UB Stadium | |
| | Baylor Bears #7 | 21 | @ | 28 | TCU Horned Frogs #19 | | 7:30 PM EST | | Amon G. Carter Stadium | ESPN |
| | Tulsa Golden Hurricane | 45 | @ | 34 | Tulane Green Wave | | 8:00 PM EST | | Mercedes-Benz Superdome | |
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| Saturday, November 28th |
| | Louisville Cardinals | 38 | @ | 24 | Kentucky Wildcats | | 12:00 PM EST | | Kroger Field | |
| | SMU Mustangs | 0 | @ | 63 | Memphis Tigers | | 12:00 PM EST | | Liberty Bowl Memorial Stadium | |
| OSU Buckeyes #8 | 42 | @ | 13 | Michigan Wolverines #10 | | 12:00 PM EST | | Michigan Stadium | |
| | Cincinnati Bearcats | 19 | @ | 16 | East Carolina Pirates | | 12:00 PM EST | | Bagwell Field at Dowdy-Ficklen Stadium | |
| | Georgia Bulldogs | 13 | @ | 7 | Georgia Tech Yellowjackets | | 12:00 PM EST | | Bobby Dodd Stadium | |
| | Indiana Hoosiers | 54 | @ | 36 | Purdue Boilermakers | | 12:00 PM EST | | Ross-Ade Stadium | |
| | FAU Owls | 33 | @ | 31 | Old Dominion Monarchs | | 12:00 PM EST | | Foreman Field at S. B. Ballard Stadium | |
| Clemson Tigers #1 | 37 | @ | 32 | South Carolina Gamecocks | | 12:00 PM EST | | Williams-Brice Stadium | |
| | Virginia Tech Hokies | 23 | @ | 20 | Virginia Cavaliers | | 12:00 PM EST | | Lane Stadium | |
| | Iowa St Cyclones | 6 | @ | 30 | West Virginia Mountaineers | | 12:00 PM EST | | Mountaineer Field at Milan Puskar Stadium | |
| | Southern Miss Golden Eagles | 58 | @ | 24 | Louisiana Tech Bulldogs | | 12:00 PM EST | | Joe Aillet Stadium | |
| | Maryland Terrapins | 46 | @ | 41 | Rutgers Scarlet Knights | | 12:00 PM EST | | High Point Solutions Stadium | |
| | Duke Blue Devils | 27 | @ | 21 | Wake Forest Demon Deacons | | 12:30 PM EST | | BB&T Field | |
| | Boston College Eagles | 17 | @ | 20 | Syracuse Orange | | 12:30 PM EST | | Carrier Dome | |
| | UNLV Rebels | 28 | @ | 35 | Wyoming Cowboys | | 2:00 PM EST | | Jonah Field at War Memorial Stadium | |
| | LA-Lafayette Ragin' Cajuns | 7 | @ | 28 | Appalachian St Mountaineers | | 2:00 PM EST | | Kidd Brewer Stadium | |
| | South Alabama Jaguars | 17 | @ | 55 | Georgia Southern Eagles | | 2:00 PM EST | | Allen E. Paulson Stadium | |
| | Colorado Buffaloes | 14 | @ | 20 | Utah Utes #23 | | 2:30 PM EST | | Rice-Eccles Stadium | |
| | Mid Tennessee Blue Raiders | 42 | @ | 7 | UTSA Roadrunners | | 2:30 PM EST | | Alamodome | |
| UCLA Bruins #22 | 21 | @ | 40 | USC Trojans | | 3:30 PM EST | | Los Angeles Memorial Coliseum | |
| | North Carolina Tar Heels #14 | 45 | @ | 34 | NC State Wolfpack | | 3:30 PM EST | | Wayne Day Family Field at Carter-Finley Stadium | |
| | Northwestern Wildcats #16 | 24 | @ | 14 | Illinois Fighting Illini | | 3:30 PM EST | | Soldier Field | |
| | Charlotte 49ers | 7 | @ | 27 | Rice Owls | | 3:30 PM EST | | Rice Stadium | |
| | Penn State Nittany Lions | 16 | @ | 55 | Michigan St Spartans #5 | | 3:30 PM EST | | Spartan Stadium | |
| | UTEP Miners | 20 | @ | 17 | North Texas Mean Green | | 3:30 PM EST | | Apogee Stadium | |
| | Wisconsin Badgers | 31 | @ | 21 | Minnesota Golden Gophers | | 3:30 PM EST | | TCF Bank Stadium | |
| | BYU Cougars | 51 | @ | 28 | Utah St Aggies | | 3:30 PM EST | | Merlin Olsen Field at Maverik Stadium | CBSSN |
| Alabama Crimson Tide #2 | 29 | @ | 13 | Auburn Tigers | | 3:30 PM EST | | Jordan-Hare Stadium | |
| | Arkansas St Red Wolves | 52 | @ | 28 | New Mexico St Aggies | | 4:00 PM EST | | Aggie Memorial Stadium | |
| | Vanderbilt Commodores | 28 | @ | 53 | Tennessee Volunteers | | 4:00 PM EST | | Neyland Stadium | |
| | Kansas St Wildcats | 45 | @ | 14 | Kansas Jayhawks | | 4:00 PM EST | | Memorial Stadium | |
| | Texas St Bobcats | 31 | @ | 38 | Idaho Vandals | | 5:00 PM EST | | Kibbie Dome | |
| | Connecticut Huskies | 3 | @ | 27 | Temple Owls #25 | | 7:00 PM EST | | Lincoln Financial Field | |
| | Ole Miss Rebels #18 | 38 | @ | 27 | Miss State Bulldogs #21 | | 7:15 PM EST | | Davis Wade Stadium | |
| | FSU Seminoles #13 | 27 | @ | 2 | Florida Gators #12 | | 7:30 PM EST | | Ben Hill Griffin Stadium at Florida Field | |
| | Texas A&M Aggies | 7 | @ | 19 | LSU Tigers | | 7:30 PM EST | | Tiger Stadium | |
| | Notre Dame Fighting Irish #6 | 36 | @ | 38 | Stanford Cardinal #9 | | 7:30 PM EST | | Stanford Stadium | |
| | Oklahoma Sooners #3 | 58 | @ | 23 | Oklahoma St Cowboys #11 | | 8:00 PM EST | | Boone Pickens Stadium | |
| | Colorado St Rams | 34 | @ | 31 | Fresno State Bulldogs | | 9:00 PM EST | | Bulldog Stadium | |
| | ASU Sun Devils | 46 | @ | 48 | Cal Golden Bears | | 10:00 PM EST | | California Memorial Stadium | |
| | Air Force Falcons | 35 | @ | 47 | New Mexico Lobos | | 10:15 PM EST | | Dreamstyle Stadium | |
| | Nevada Wolf Pack | 14 | @ | 31 | San Diego St Aztecs | | 10:45 PM EST | | Qualcomm Stadium | |
| | LA-Monroe Warhawks | 26 | @ | 28 | Hawaii Warriors | | 11:00 PM EST | | JPS Field at Malone Stadium | |