| Thursday, September 22nd |
| | Clemson Tigers | 26 | @ | 7 | Georgia Tech Yellowjackets |  | 7:30 PM EDT | | Bobby Dodd Stadium | |
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| Friday, September 23rd |
| | Wyoming Cowboys | 24 | @ | 27 | E Michigan Eagles | | 7:30 PM EDT | | Rynearson Stadium | |
| | TCU Horned Frogs | 33 | @ | 3 | SMU Mustangs | | 8:00 PM EDT | | Gerald Ford Stadium | |
| | USC Trojans | 27 | @ | 31 | Utah Utes |  | 9:00 PM EDT | | Rice-Eccles Stadium | |
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| Saturday, September 24th |
| | FSU Seminoles #13 | 55 | @ | 35 | USF Bulls | | 12:00 PM EDT | | Raymond James Stadium | |
| | Colorado St Rams | 24 | @ | 31 | Minnesota Golden Gophers | | 12:00 PM EDT | | TCF Bank Stadium | |
| | Charlotte 49ers | 20 | @ | 48 | Temple Owls | | 12:00 PM EDT | | Lincoln Financial Field | |
| | Kent St Golden Flashes | 0 | @ | 48 | Alabama Crimson Tide #1 | | 12:00 PM EDT | | Bryant-Denny Stadium | |
| | San Jose St Spartans | 10 | @ | 44 | Iowa St Cyclones | | 12:00 PM EDT | | Jack Trice Stadium | |
| | Iowa Hawkeyes | 14 | @ | 7 | Rutgers Scarlet Knights |  | 12:00 PM EDT | | High Point Solutions Stadium | |
| | Georgia Bulldogs #12 | 14 | @ | 45 | Ole Miss Rebels #23 |  | 12:00 PM EDT | | Vaught-Hemingway Stadium | ESPN |
| | Nevada Wolf Pack | 14 | @ | 24 | Purdue Boilermakers | | 12:00 PM EDT | | Ross-Ade Stadium | |
| | Wisconsin Badgers | 30 | @ | 6 | Michigan St Spartans | | 12:00 PM EDT | | Spartan Stadium | |
| | East Carolina Pirates | 17 | @ | 54 | Virginia Tech Hokies | | 12:30 PM EDT | | Lane Stadium | |
| | Cent Michigan Chippewas | 35 | @ | 49 | Virginia Cavaliers | | 12:30 PM EDT | | Scott Stadium | |
| | Syracuse Orange | 31 | @ | 24 | Connecticut Huskies | | 1:00 PM EDT | | Pratt and Whitney Stadium at Rentschler Field | |
| | Wagner Seahawks | 10 | @ | 42 | Boston College Eagles | | 1:00 PM EDT | | Alumni Stadium | |
| | Gardner-Webb Runnin' Bulldogs | 21 | @ | 37 | Ohio Bobcats | | 2:00 PM EDT | | Peden Stadium | |
| | Penn State Nittany Lions | 10 | @ | 49 | Michigan Wolverines | | 3:30 PM EDT | | Michigan Stadium | |
| | Boise St Broncos | 38 | @ | 24 | Oregon St Beavers | | 3:30 PM EDT | | Reser Stadium | |
| | Wake Forest Demon Deacons | 33 | @ | 28 | Indiana Hoosiers | | 3:30 PM EDT | | Memorial Stadium | |
| | Appalachian St Mountaineers | 45 | @ | 38 | Akron Zips | | 3:30 PM EDT | | InfoCision Stadium | |
| | UTSA Roadrunners | 19 | @ | 33 | Old Dominion Monarchs |  | 3:30 PM EDT | | Foreman Field at S. B. Ballard Stadium | |
| | Pittsburgh Panthers | 36 | @ | 37 | North Carolina Tar Heels | | 3:30 PM EDT | | Kenan Memorial Stadium | |
| Florida Gators #19 | 28 | @ | 38 | Tennessee Volunteers #14 | | 3:30 PM EDT | | Neyland Stadium | |
| | Miami (OH) RedHawks | 20 | @ | 27 | Cincinnati Bearcats | | 3:30 PM EDT | | Nippert Stadium | |
| | BYU Cougars | 32 | @ | 35 | West Virginia Mountaineers | | 3:30 PM EDT | | FedExField | |
| | W Ill Leathernecks | 28 | @ | 23 | N Illinois Huskies | | 3:30 PM EDT | | Brigham Field at Huskie Stadium | |
| | Duke Blue Devils | 38 | @ | 35 | Notre Dame Fighting Irish | | 3:30 PM EDT | | Notre Dame Stadium | |
| | Miss State Bulldogs | 47 | @ | 35 | Massachusetts Minutemen | | 3:30 PM EDT | | Warren McGuirk Alumni Stadium | |
| | Delaware St Hornets | 0 | @ | 79 | Missouri Tigers | | 4:00 PM EDT | | Faurot Field at Memorial Stadium | |
| | Tulsa Golden Hurricane | 48 | @ | 41 | Fresno State Bulldogs | | 4:30 PM EDT | | Bulldog Stadium | |
| | Vanderbilt Commodores | 31 | @ | 30 | W Kentucky Hilltoppers | | 4:30 PM EDT | | Houchens Industries-L.T. Smith Stadium | |
| | Colorado Buffaloes | 41 | @ | 38 | Oregon Ducks | | 5:30 PM EDT | | Autzen Stadium | |
| | North Texas Mean Green | 42 | @ | 35 | Rice Owls | | 6:00 PM EDT | | Rice Stadium | |
| | LSU Tigers #18 | 13 | @ | 18 | Auburn Tigers | | 6:00 PM EDT | | Jordan-Hare Stadium | |
| | Furman Paladins | 21 | @ | 41 | Coast Carolina Chanticleers | | 6:00 PM EDT | | Brooks Field at Wallace Wade Stadium | |
| | Ball St Cardinals | 31 | @ | 27 | FAU Owls | | 6:00 PM EDT | | FAU Stadium | |
| | UCF Knights | 53 | @ | 14 | Florida Int Golden Panthers | | 7:00 PM EDT | | Riccardo Silva Stadium | |
| | Louisiana Tech Bulldogs | 34 | @ | 38 | Mid Tennessee Blue Raiders | | 7:00 PM EDT | | Johnny Red Floyd Stadium | |
| | Nicholls St Colonels | 40 | @ | 41 | South Alabama Jaguars | | 7:00 PM EDT | | Ladd-Peebles Stadium | |
| | New Mexico St Aggies | 6 | @ | 52 | Troy Trojans |  | 7:00 PM EDT | | Veterans Memorial Stadium | |
| | Cent Arkansas Bears | 28 | @ | 23 | Arkansas St Red Wolves | | 7:00 PM EDT | | Centennial Bank Stadium | |
| | Georgia Southern Eagles | 31 | @ | 49 | W Michigan Broncos | | 7:00 PM EDT | | Waldo Stadium | |
| | Houston Cougars | 64 | @ | 3 | Texas St Bobcats | | 7:00 PM EDT | | Jim Wacker Field at Bobcat Stadium | |
| | Army Black Knights | 20 | @ | 23 | Buffalo Bulls | | 7:00 PM EDT | | UB Stadium | |
| | Missouri St Bears | 0 | @ | 35 | Kansas St Wildcats | | 7:10 PM EDT | | Bill Snyder Family Stadium | |
| | South Carolina Gamecocks | 10 | @ | 17 | Kentucky Wildcats | | 7:30 PM EDT | | Kroger Field | |
| | Oklahoma St Cowboys | 24 | @ | 35 | Baylor Bears |  | 7:30 PM EDT | | McLane Stadium | |
| | Nebraska Cornhuskers | 24 | @ | 13 | Northwestern Wildcats | | 7:30 PM EDT | | Ryan Field | |
| | Bowling Green Falcons | 3 | @ | 77 | Memphis Tigers | | 8:00 PM EDT | | Liberty Bowl Memorial Stadium | |
| | LA-Lafayette Ragin' Cajuns | 39 | @ | 41 | Tulane Green Wave | | 8:00 PM EDT | | Yulman Stadium | |
| | Louisville Cardinals | 59 | @ | 28 | Marshall Thundering Herd | | 8:00 PM EDT | | Joan C. Edwards Stadium | |
| | Stanford Cardinal | 22 | @ | 13 | UCLA Bruins | | 8:00 PM EDT | | Rose Bowl | |
| | Southern Miss Golden Eagles | 34 | @ | 7 | UTEP Miners | | 8:00 PM EDT | | Sun Bowl | |
| | Idaho Vandals | 33 | @ | 30 | UNLV Rebels | | 9:00 PM EDT | | Sam Boyd Stadium | |
| | Arkansas Razorbacks #17 | 24 | @ | 45 | Texas A&M Aggies #10 | | 9:00 PM EDT | | AT&T Stadium | ESPN |
| | Cal Golden Bears | 41 | @ | 51 | ASU Sun Devils | | 10:00 PM EDT | | Sun Devil Stadium | |
| | Air Force Falcons | 27 | @ | 20 | Utah St Aggies |  | 10:15 PM EDT | | Merlin Olsen Field at Maverik Stadium | |
| | Washington Huskies | 35 | @ | 28 | Arizona Wildcats | | 10:30 PM EDT | | Arizona Stadium | |