Thursday, September 22nd |
| Clemson Tigers | 26 | @ | 7 | Georgia Tech Yellowjackets |  | 7:30 PM EDT | | Bobby Dodd Stadium | |
|
Friday, September 23rd |
| Wyoming Cowboys | 24 | @ | 27 | E Michigan Eagles | | 7:30 PM EDT | | Rynearson Stadium | |
| TCU Horned Frogs | 33 | @ | 3 | SMU Mustangs | | 8:00 PM EDT | | Gerald Ford Stadium | |
| USC Trojans | 27 | @ | 31 | Utah Utes |  | 9:00 PM EDT | | Rice-Eccles Stadium | |
|
Saturday, September 24th |
| Nevada Wolf Pack | 14 | @ | 24 | Purdue Boilermakers | | 12:00 PM EDT | | Ross-Ade Stadium | |
| Wisconsin Badgers | 30 | @ | 6 | Michigan St Spartans |  | 12:00 PM EDT | | Spartan Stadium | |
| FSU Seminoles #13 | 55 | @ | 35 | USF Bulls | | 12:00 PM EDT | | Raymond James Stadium | |
| Colorado St Rams | 24 | @ | 31 | Minnesota Golden Gophers | | 12:00 PM EDT | | TCF Bank Stadium | |
| Charlotte 49ers | 20 | @ | 48 | Temple Owls | | 12:00 PM EDT | | Lincoln Financial Field | |
| Kent St Golden Flashes | 0 | @ | 48 | Alabama Crimson Tide #1 | | 12:00 PM EDT | | Bryant-Denny Stadium | |
| San Jose St Spartans | 10 | @ | 44 | Iowa St Cyclones | | 12:00 PM EDT | | Jack Trice Stadium | |
| Iowa Hawkeyes | 14 | @ | 7 | Rutgers Scarlet Knights |  | 12:00 PM EDT | | High Point Solutions Stadium | |
| Georgia Bulldogs #12 | 14 | @ | 45 | Ole Miss Rebels #23 |  | 12:00 PM EDT | | Vaught-Hemingway Stadium | ESPN |
| Cent Michigan Chippewas | 35 | @ | 49 | Virginia Cavaliers | | 12:30 PM EDT | | Scott Stadium | |
| East Carolina Pirates | 17 | @ | 54 | Virginia Tech Hokies | | 12:30 PM EDT | | Lane Stadium | |
| Syracuse Orange | 31 | @ | 24 | Connecticut Huskies | | 1:00 PM EDT | | Pratt and Whitney Stadium at Rentschler Field | |
| Wagner Seahawks | 10 | @ | 42 | Boston College Eagles | | 1:00 PM EDT | | Alumni Stadium | |
| Gardner-Webb Runnin' Bulldogs | 21 | @ | 37 | Ohio Bobcats | | 2:00 PM EDT | | Peden Stadium | |
| W Ill Leathernecks | 28 | @ | 23 | N Illinois Huskies | | 3:30 PM EDT | | Brigham Field at Huskie Stadium | |
| Duke Blue Devils | 38 | @ | 35 | Notre Dame Fighting Irish | | 3:30 PM EDT | | Notre Dame Stadium | |
| Miss State Bulldogs | 47 | @ | 35 | Massachusetts Minutemen | | 3:30 PM EDT | | Warren McGuirk Alumni Stadium | |
| Penn State Nittany Lions | 10 | @ | 49 | Michigan Wolverines |  | 3:30 PM EDT | | Michigan Stadium | |
| Boise St Broncos | 38 | @ | 24 | Oregon St Beavers | | 3:30 PM EDT | | Reser Stadium | |
| Wake Forest Demon Deacons | 33 | @ | 28 | Indiana Hoosiers | | 3:30 PM EDT | | Memorial Stadium | |
| Appalachian St Mountaineers | 45 | @ | 38 | Akron Zips | | 3:30 PM EDT | | InfoCision Stadium | |
| UTSA Roadrunners | 19 | @ | 33 | Old Dominion Monarchs |  | 3:30 PM EDT | | Foreman Field at S. B. Ballard Stadium | |
| Pittsburgh Panthers | 36 | @ | 37 | North Carolina Tar Heels |  | 3:30 PM EDT | | Kenan Memorial Stadium | |
| Florida Gators #19 | 28 | @ | 38 | Tennessee Volunteers #14 |  | 3:30 PM EDT | | Neyland Stadium | |
| Miami (OH) RedHawks | 20 | @ | 27 | Cincinnati Bearcats | | 3:30 PM EDT | | Nippert Stadium | |
| BYU Cougars | 32 | @ | 35 | West Virginia Mountaineers | | 3:30 PM EDT | | FedExField | |
| Delaware St Hornets | 0 | @ | 79 | Missouri Tigers | | 4:00 PM EDT | | Faurot Field at Memorial Stadium | |
| Tulsa Golden Hurricane | 48 | @ | 41 | Fresno State Bulldogs | | 4:30 PM EDT | | Bulldog Stadium | |
| Vanderbilt Commodores | 31 | @ | 30 | W Kentucky Hilltoppers | | 4:30 PM EDT | | Houchens Industries-L.T. Smith Stadium | |
| Colorado Buffaloes | 41 | @ | 38 | Oregon Ducks |  | 5:30 PM EDT | | Autzen Stadium | |
| Ball St Cardinals | 31 | @ | 27 | FAU Owls | | 6:00 PM EDT | | FAU Stadium | |
| North Texas Mean Green | 42 | @ | 35 | Rice Owls |  | 6:00 PM EDT | | Rice Stadium | |
| LSU Tigers #18 | 13 | @ | 18 | Auburn Tigers |  | 6:00 PM EDT | | Jordan-Hare Stadium | |
| Furman Paladins | 21 | @ | 41 | Coast Carolina Chanticleers | | 6:00 PM EDT | | Brooks Field at Wallace Wade Stadium | |
| Georgia Southern Eagles | 31 | @ | 49 | W Michigan Broncos | | 7:00 PM EDT | | Waldo Stadium | |
| Houston Cougars | 64 | @ | 3 | Texas St Bobcats | | 7:00 PM EDT | | Jim Wacker Field at Bobcat Stadium | |
| Army Black Knights | 20 | @ | 23 | Buffalo Bulls | | 7:00 PM EDT | | UB Stadium | |
| UCF Knights | 53 | @ | 14 | Florida Int Golden Panthers | | 7:00 PM EDT | | Riccardo Silva Stadium | |
| Louisiana Tech Bulldogs | 34 | @ | 38 | Mid Tennessee Blue Raiders |  | 7:00 PM EDT | | Johnny Red Floyd Stadium | |
| Nicholls St Colonels | 40 | @ | 41 | South Alabama Jaguars | | 7:00 PM EDT | | Ladd-Peebles Stadium | |
| New Mexico St Aggies | 6 | @ | 52 | Troy Trojans |  | 7:00 PM EDT | | Veterans Memorial Stadium | |
| Cent Arkansas Bears | 28 | @ | 23 | Arkansas St Red Wolves | | 7:00 PM EDT | | Centennial Bank Stadium | |
| Missouri St Bears | 0 | @ | 35 | Kansas St Wildcats | | 7:10 PM EDT | | Bill Snyder Family Stadium | |
| Nebraska Cornhuskers | 24 | @ | 13 | Northwestern Wildcats |  | 7:30 PM EDT | | Ryan Field | |
| South Carolina Gamecocks | 10 | @ | 17 | Kentucky Wildcats |  | 7:30 PM EDT | | Kroger Field | |
| Oklahoma St Cowboys | 24 | @ | 35 | Baylor Bears |  | 7:30 PM EDT | | McLane Stadium | |
| Southern Miss Golden Eagles | 34 | @ | 7 | UTEP Miners |  | 8:00 PM EDT | | Sun Bowl | |
| Bowling Green Falcons | 3 | @ | 77 | Memphis Tigers | | 8:00 PM EDT | | Liberty Bowl Memorial Stadium | |
| LA-Lafayette Ragin' Cajuns | 39 | @ | 41 | Tulane Green Wave | | 8:00 PM EDT | | Yulman Stadium | |
| Louisville Cardinals | 59 | @ | 28 | Marshall Thundering Herd | | 8:00 PM EDT | | Joan C. Edwards Stadium | |
| Stanford Cardinal | 22 | @ | 13 | UCLA Bruins |  | 8:00 PM EDT | | Rose Bowl | |
| Idaho Vandals | 33 | @ | 30 | UNLV Rebels | | 9:00 PM EDT | | Sam Boyd Stadium | |
| Arkansas Razorbacks #17 | 24 | @ | 45 | Texas A&M Aggies #10 |  | 9:00 PM EDT | | AT&T Stadium | ESPN |
| Cal Golden Bears | 41 | @ | 51 | ASU Sun Devils |  | 10:00 PM EDT | | Sun Devil Stadium | |
| Air Force Falcons | 27 | @ | 20 | Utah St Aggies |  | 10:15 PM EDT | | Merlin Olsen Field at Maverik Stadium | |
| Washington Huskies | 35 | @ | 28 | Arizona Wildcats |  | 10:30 PM EDT | | Arizona Stadium | |