| Thursday, September 29th |
| | Connecticut Huskies | 14 | @ | 42 | Houston Cougars |  | 8:00 PM EDT | | John O'Quinn Field at TDECU Stadium | |
| | Kansas Jayhawks | 19 | @ | 55 | Texas Tech Red Raiders |  | 8:30 PM EDT | | Jones AT&T Stadium | |
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| Friday, September 30th |
| | Stanford Cardinal | 6 | @ | 44 | Washington Huskies |  | 9:00 PM EDT | | Alaska Airlines Field at Husky Stadium | |
| | Toledo Rockets | 53 | @ | 55 | BYU Cougars | | 10:15 PM EDT | | LaVell Edwards Stadium | |
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| Saturday, October 1st |
| | SMU Mustangs | 20 | @ | 45 | Temple Owls | | 12:00 PM EDT | | Lincoln Financial Field | |
| | Texas Longhorns | 31 | @ | 49 | Oklahoma St Cowboys | | 12:00 PM EDT | | Boone Pickens Stadium | |
| | Baylor Bears | 45 | @ | 42 | Iowa St Cyclones | | 12:00 PM EDT | | Jack Trice Stadium | |
| | Alcorn St Braves | 10 | @ | 52 | Arkansas Razorbacks #20 | | 12:00 PM EDT | | Donald W. Reynolds Razorback Stadium | |
| | Northwestern Wildcats | 38 | @ | 31 | Iowa Hawkeyes |  | 12:00 PM EDT | | Kinnick Stadium | |
| | UCF Knights | 47 | @ | 29 | East Carolina Pirates | | 12:00 PM EDT | | Bagwell Field at Dowdy-Ficklen Stadium | |
| | Rutgers Scarlet Knights | 0 | @ | 58 | OSU Buckeyes | | 12:00 PM EDT | | Ohio Stadium | |
| | Georgia St Panthers | 3 | @ | 17 | Appalachian St Mountaineers |  | 12:00 PM EDT | | Kidd Brewer Stadium | |
| | Miami (FL) Hurricanes | 35 | @ | 21 | Georgia Tech Yellowjackets |  | 12:00 PM EDT | | Bobby Dodd Stadium | |
| | Florida Gators #23 | 13 | @ | 6 | Vanderbilt Commodores |  | 12:00 PM EDT | | Vanderbilt Stadium | |
| | Notre Dame Fighting Irish | 50 | @ | 33 | Syracuse Orange | | 12:00 PM EDT | | MetLife Stadium | |
| | Virginia Cavaliers | 34 | @ | 20 | Duke Blue Devils | | 12:30 PM EDT | | Brooks Field at Wallace Wade Stadium | |
| | Buffalo Bulls | 3 | @ | 35 | Boston College Eagles | | 1:00 PM EDT | | Alumni Stadium | |
| | Ohio Bobcats | 17 | @ | 7 | Miami (OH) RedHawks |  | 2:30 PM EDT | | Fred C. Yager Stadium | |
| | Oregon St Beavers | 6 | @ | 47 | Colorado Buffaloes | | 2:30 PM EDT | | Folsom Field | |
| | E Michigan Eagles | 28 | @ | 25 | Bowling Green Falcons | | 3:00 PM EDT | | Doyt L. Perry Stadium | |
| | Tulane Green Wave | 31 | @ | 24 | Massachusetts Minutemen | | 3:30 PM EDT | | Warren McGuirk Alumni Stadium | |
| | Kansas St Wildcats | 16 | @ | 17 | West Virginia Mountaineers | | 3:30 PM EDT | | Mountaineer Field at Milan Puskar Stadium | |
| | Tennessee Volunteers #11 | 34 | @ | 31 | Georgia Bulldogs #25 | | 3:30 PM EDT | | Sanford Stadium | |
| | Purdue Boilermakers | 7 | @ | 50 | Maryland Terrapins | | 3:30 PM EDT | | Capital One Field at Byrd Stadium | |
| | Illinois Fighting Illini | 16 | @ | 31 | Nebraska Cornhuskers | | 3:30 PM EDT | | Memorial Stadium | |
| | Minnesota Golden Gophers | 26 | @ | 29 | Penn State Nittany Lions | | 3:30 PM EDT | | Beaver Stadium | |
| | Akron Zips | 31 | @ | 27 | Kent St Golden Flashes | | 3:30 PM EDT | | Dix Stadium | |
| | LA-Monroe Warhawks | 7 | @ | 58 | Auburn Tigers | | 3:30 PM EDT | | Jordan-Hare Stadium | SECN |
| | Wake Forest Demon Deacons | 16 | @ | 33 | NC State Wolfpack | | 3:30 PM EDT | | Wayne Day Family Field at Carter-Finley Stadium | |
| | North Carolina Tar Heels | 37 | @ | 35 | FSU Seminoles #12 | | 3:30 PM EDT | | Bobby Bowden Field at Doak Campbell Stadium | |
| | Wisconsin Badgers | 7 | @ | 14 | Michigan Wolverines | | 3:30 PM EDT | | Michigan Stadium | |
| | N Illinois Huskies | 31 | @ | 24 | Ball St Cardinals | | 3:30 PM EDT | | Scheumann Stadium | |
| | Navy Midshipmen | 14 | @ | 28 | Air Force Falcons | | 3:30 PM EDT | | Falcon Stadium | |
| | Texas A&M Aggies #9 | 24 | @ | 13 | South Carolina Gamecocks | | 4:00 PM EDT | | Williams-Brice Stadium | |
| | San Jose St Spartans | 41 | @ | 48 | New Mexico Lobos |  | 4:00 PM EDT | | Dreamstyle Stadium | |
| | Oklahoma Sooners | 52 | @ | 46 | TCU Horned Frogs | | 5:00 PM EDT | | Amon G. Carter Stadium | |
| | Troy Trojans | 34 | @ | 13 | Idaho Vandals | | 5:00 PM EDT | | Kibbie Dome | |
| | CSU Buccaneers | 59 | @ | 58 | Coast Carolina Chanticleers |  | 6:00 PM EDT | | Brooks Stadium | |
| | Utah Utes | 23 | @ | 28 | Cal Golden Bears | | 6:00 PM EDT | | California Memorial Stadium | |
| | Old Dominion Monarchs | 52 | @ | 17 | Charlotte 49ers |  | 6:00 PM EDT | | Jerry Richardson Stadium | |
| | FAU Owls | 31 | @ | 33 | Florida Int Golden Panthers | | 7:00 PM EDT | | Riccardo Silva Stadium | |
| | USF Bulls | 45 | @ | 20 | Cincinnati Bearcats | | 7:00 PM EDT | | Nippert Stadium | |
| | Rice Owls | 28 | @ | 44 | Southern Miss Golden Eagles | | 7:00 PM EDT | | M.M. Roberts Stadium | |
| | Houston Baptist Huskies | 3 | @ | 50 | W Kentucky Hilltoppers | | 7:00 PM EDT | | Houchens Industries-L.T. Smith Stadium | |
| | W Michigan Broncos | 49 | @ | 10 | Cent Michigan Chippewas | | 7:00 PM EDT | | Kelly/Shorts Stadium | |
| | UTEP Miners | 7 | @ | 28 | Louisiana Tech Bulldogs | | 7:00 PM EDT | | Joe Aillet Stadium | |
| | Mid Tennessee Blue Raiders | 30 | @ | 13 | North Texas Mean Green | | 7:00 PM EDT | | Apogee Stadium | |
| | Kentucky Wildcats | 6 | @ | 34 | Alabama Crimson Tide #1 | | 7:00 PM EDT | | Bryant-Denny Stadium | |
| | Memphis Tigers | 28 | @ | 48 | Ole Miss Rebels #16 | | 7:00 PM EDT | | Vaught-Hemingway Stadium | |
| | Incarnate Word Cardinals | 17 | @ | 48 | Texas St Bobcats | | 7:30 PM EDT | | Jim Wacker Field at Bobcat Stadium | |
| | Missouri Tigers | 7 | @ | 42 | LSU Tigers | | 7:30 PM EDT | | Tiger Stadium | |
| | Marshall Thundering Herd | 27 | @ | 43 | Pittsburgh Panthers | | 7:30 PM EDT | | Heinz Field | |
| | Michigan St Spartans | 21 | @ | 24 | Indiana Hoosiers | | 8:00 PM EDT | | Memorial Stadium | |
| | LA-Lafayette Ragin' Cajuns | 31 | @ | 37 | New Mexico St Aggies | | 8:00 PM EDT | | Aggie Memorial Stadium | |
| | Louisville Cardinals | 36 | @ | 42 | Clemson Tigers | | 8:00 PM EDT | | Memorial Stadium | |
| | San Diego St Aztecs | 24 | @ | 42 | South Alabama Jaguars | | 8:00 PM EDT | | Ladd-Peebles Stadium | |
| | ASU Sun Devils | 20 | @ | 41 | USC Trojans | | 8:30 PM EDT | | Los Angeles Memorial Coliseum | |
| | Oregon Ducks | 33 | @ | 51 | Washington St Cougars | | 9:30 PM EDT | | Martin Stadium | |
| | Utah St Aggies | 10 | @ | 21 | Boise St Broncos | | 10:15 PM EDT | | Albertsons Stadium | |
| | Wyoming Cowboys | 38 | @ | 17 | Colorado St Rams | | 10:15 PM EDT | | Sonny Lubick Field at Hughes Stadium | |
| | Arizona Wildcats | 24 | @ | 45 | UCLA Bruins | | 10:30 PM EDT | | Rose Bowl | |
| | Fresno State Bulldogs | 20 | @ | 45 | UNLV Rebels | | 10:30 PM EDT | | Sam Boyd Stadium | |
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| Sunday, October 2nd |
| | Nevada Wolf Pack | 17 | @ | 38 | Hawaii Warriors | | | | Hawaiian Tel Federal Credit Union Field | |