| Wednesday, October 5th |
| | Georgia Southern Eagles | 26 | @ | 27 | Arkansas St Red Wolves |  | 8:00 PM EDT | | Centennial Bank Stadium | |
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| Thursday, October 6th |
| | Temple Owls | 27 | @ | 34 | Memphis Tigers |  | 8:00 PM EDT | | Liberty Bowl Memorial Stadium | |
| | W Kentucky Hilltoppers | 52 | @ | 55 | Louisiana Tech Bulldogs |  | 8:00 PM EDT | | Joe Aillet Stadium | |
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| Friday, October 7th |
| | Clemson Tigers | 56 | @ | 10 | Boston College Eagles |  | 7:30 PM EDT | | Alumni Stadium | |
| | Massachusetts Minutemen | 16 | @ | 36 | Old Dominion Monarchs | | 8:00 PM EDT | | Foreman Field at S. B. Ballard Stadium | |
| | SMU Mustangs | 40 | @ | 43 | Tulsa Golden Hurricane | | 8:00 PM EDT | | Skelly Field at H. A. Chapman Stadium | |
| | Boise St Broncos | 49 | @ | 21 | New Mexico Lobos |  | 9:00 PM EDT | | Dreamstyle Stadium | |
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| Saturday, October 8th |
| | Cincinnati Bearcats | 9 | @ | 20 | Connecticut Huskies | | 11:30 AM EDT | | Pratt and Whitney Stadium at Rentschler Field | |
| | Auburn Tigers | 38 | @ | 14 | Miss State Bulldogs |  | 12:00 PM EDT | | Davis Wade Stadium | SECN |
| | Maryland Terrapins | 14 | @ | 38 | Penn State Nittany Lions |  | 12:00 PM EDT | | Beaver Stadium | |
| | East Carolina Pirates | 22 | @ | 38 | USF Bulls | | 12:00 PM EDT | | Raymond James Stadium | |
| | Southern Miss Golden Eagles | 32 | @ | 55 | UTSA Roadrunners | | 12:00 PM EDT | | Alamodome | |
| | Iowa Hawkeyes | 14 | @ | 7 | Minnesota Golden Gophers | | 12:00 PM EDT | | TCF Bank Stadium | |
| | TCU Horned Frogs | 24 | @ | 23 | Kansas Jayhawks |  | 12:00 PM EDT | | Memorial Stadium | |
| | Oklahoma Sooners | 45 | @ | 40 | Texas Longhorns | | 12:00 PM EDT | | Cotton Bowl | |
| | Notre Dame Fighting Irish | 3 | @ | 10 | NC State Wolfpack | | 12:00 PM EDT | | Wayne Day Family Field at Carter-Finley Stadium | |
| | Georgia Tech Yellowjackets | 34 | @ | 37 | Pittsburgh Panthers | | 12:30 PM EDT | | Heinz Field | |
| | Bowling Green Falcons | 24 | @ | 30 | Ohio Bobcats |  | 2:00 PM EDT | | Peden Stadium | |
| | Toledo Rockets | 35 | @ | 20 | E Michigan Eagles | | 3:00 PM EDT | | Rynearson Stadium | |
| | Houston Cougars | 40 | @ | 46 | Navy Midshipmen | | 3:00 PM EDT | | Navy-Marine Corps Memorial Stadium | |
| | Miami (OH) RedHawks | 13 | @ | 35 | Akron Zips | | 3:00 PM EDT | | InfoCision Stadium | |
| | Virginia Tech Hokies | 34 | @ | 3 | North Carolina Tar Heels | | 3:30 PM EDT | | Kenan Memorial Stadium | |
| | Purdue Boilermakers | 34 | @ | 31 | Illinois Fighting Illini | | 3:30 PM EDT | | Memorial Stadium | |
| | Ball St Cardinals | 21 | @ | 24 | Cent Michigan Chippewas | | 3:30 PM EDT | | Kelly/Shorts Stadium | |
| | BYU Cougars | 31 | @ | 14 | Michigan St Spartans | | 3:30 PM EDT | | Spartan Stadium | |
| | Iowa St Cyclones | 31 | @ | 38 | Oklahoma St Cowboys | | 3:30 PM EDT | | Boone Pickens Stadium | |
| | Kent St Golden Flashes | 44 | @ | 20 | Buffalo Bulls | | 3:30 PM EDT | | UB Stadium | |
| | Texas St Bobcats | 21 | @ | 41 | Georgia St Panthers | | 3:30 PM EDT | | Georgia Dome | |
| | Army Black Knights | 6 | @ | 13 | Duke Blue Devils | | 3:30 PM EDT | | Brooks Field at Wallace Wade Stadium | |
| | Indiana Hoosiers | 17 | @ | 38 | OSU Buckeyes | | 3:30 PM EDT | | Ohio Stadium | |
| | Air Force Falcons | 26 | @ | 35 | Wyoming Cowboys | | 3:30 PM EDT | | Jonah Field at War Memorial Stadium | |
| | Tennessee Volunteers #9 | 38 | @ | 45 | Texas A&M Aggies #8 | | 3:30 PM EDT | | Kyle Field | |
| | Vanderbilt Commodores | 13 | @ | 20 | Kentucky Wildcats | | 4:00 PM EDT | | Kroger Field | |
| | Colorado Buffaloes | 17 | @ | 21 | USC Trojans |  | 4:00 PM EDT | | Los Angeles Memorial Coliseum | |
| | Hawaii Warriors | 34 | @ | 17 | San Jose St Spartans | | 4:30 PM EDT | | CEFCU Stadium | |
| | N Illinois Huskies | 30 | @ | 45 | W Michigan Broncos | | 6:30 PM EDT | | Waldo Stadium | |
| | Idaho Vandals | 34 | @ | 31 | LA-Monroe Warhawks | | 7:00 PM EDT | | JPS Field at Malone Stadium | |
| | Syracuse Orange | 9 | @ | 28 | Wake Forest Demon Deacons | | 7:00 PM EDT | | BB&T Field | |
| | Fresno State Bulldogs | 22 | @ | 27 | Nevada Wolf Pack | | 7:00 PM EDT | | Mackay Stadium | |
| | Marshall Thundering Herd | 21 | @ | 38 | North Texas Mean Green | | 7:00 PM EDT | | Apogee Stadium | |
| | Alabama Crimson Tide #1 | 49 | @ | 30 | Arkansas Razorbacks #16 | | 7:00 PM EDT | | Donald W. Reynolds Razorback Stadium | |
| | Michigan Wolverines | 78 | @ | 0 | Rutgers Scarlet Knights | | 7:00 PM EDT | | High Point Solutions Stadium | |
| | Texas Tech Red Raiders | 38 | @ | 44 | Kansas St Wildcats | | 7:00 PM EDT | | Bill Snyder Family Stadium | |
| | Washington Huskies | 70 | @ | 21 | Oregon Ducks | | 7:30 PM EDT | | Autzen Stadium | |
| FSU Seminoles #23 | 20 | @ | 19 | Miami (FL) Hurricanes #10 | | 8:00 PM EDT | | Hard Rock Stadium | ABC |
| | Florida Int Golden Panthers | 35 | @ | 21 | UTEP Miners | | 8:00 PM EDT | | Sun Bowl | |
| | Cal Golden Bears | 44 | @ | 47 | Oregon St Beavers | | 9:00 PM EDT | | Reser Stadium | |
| | Utah St Aggies | 24 | @ | 31 | Colorado St Rams | | 10:00 PM EDT | | Sonny Lubick Field at Hughes Stadium | |
| | Arizona Wildcats | 23 | @ | 36 | Utah Utes | | 10:00 PM EDT | | Rice-Eccles Stadium | |
| | UCLA Bruins | 20 | @ | 23 | ASU Sun Devils | | 10:30 PM EDT | | Sun Devil Stadium | |
| | UNLV Rebels | 7 | @ | 26 | San Diego St Aztecs | | 10:30 PM EDT | | Qualcomm Stadium | |
| | Washington St Cougars | 42 | @ | 16 | Stanford Cardinal | | 10:30 PM EDT | | Stanford Stadium | |
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| Sunday, October 9th |
| | Charlotte 49ers | 28 | @ | 23 | FAU Owls | | 12:00 PM EDT | | FAU Stadium | |
| | Georgia Bulldogs | 28 | @ | 14 | South Carolina Gamecocks | | 2:30 PM EDT | | Williams-Brice Stadium | |